Ensure you enter your valid MODELLER key via the BioSerf tab.

You input looks like it may be a multiple sequence alignment, please ensure it is in valid fasta format and that all sequences are the same length


Web Servers

The Bioinformatics Group places a great deal of emphasis on developing Web services which are widely used by many groups and institutions. These include psipred, genTHREADER and disopred. We additionally offer all our servers via SOAP and XML-RPC (see these instructions for details). If you wish to link to our servers please feel free to do so, you may wish to read our Smart Links guide for further information. For commercial enquiries about our software services, please visit Ebisu


Protein Fold Recognition

These methods will identify putative folds and structural domains for a sequence without known structure.

GenTHREADER Rapid fold recognition, matching your sequence against a library of whole PDB chains.
pGenTHREADER Highly sensitive fold recognition using profile-profile comparison (whole chain library).
pDomTHREADER Highly sensitive homologous domain recognition using profile-profile comparison (domain library).

Protein Structure Feature Recognition

These methods annotate sequences with the location of important structural features.

PSIPRED Accurate protein secondary structure prediction.
METSITE A method for identifying metal binding sites in protein 3D structures

Transmembrane Topology Prediction

These methods identify the topology of putative transmembrane proteins.

MEMSAT3 Transmembrane protein topology predcition.
MEMSATSVM Improved transmembrane protein topology prediction using SVMs. This method is capable of differentiating signal peptides from transmembrane helices.
MEMEMBED Prediction of Membrane protein orientation.

3D Protein Modelling

Our latest experimental method will generate a homology model for a given sequence.

BioSerf Automated homology and de-novo modelling server, utilising Modeller, PSIBLAST, pGenTHREADER and HHBlits.
DomSerf Automated homology modelling of protein domains.

Annotation of Protein Sequence Features

These methods identify protein sequence features which are important for protein structure and function.

DomPred Identifies putative domain boundaries in sequences.
DISOPRED Identifies residues which are likely to be natively unfolded (disordered).

Protein Interface Characterisation

Characterisation of protein-protein interfaces.

HSPred Interface Hot Spot Prediction

Function Prediction

Feature-based protein function prediction from amino acid sequence.

FFPred Integrated function prediction

Web Services

We now offer all our online methods as SOAP and XML-RPC web services. Please read the Web Service notes before using


WSDLWSDL for our services


Legacy Services

The following services are unmaintained and due to be retired. Data and access is provided on an "as is" basis.

GTD Genomic Threading Database
COPS Comparison Of Protein Structure classifications