Web Servers

The Bioinformatics Group places a great deal of emphasis on developing Web services which are widely used by many groups and institutions. These include psipred, genTHREADER and disopred. We additionally offer all our servers via REST (see these instructions for details).for further information. For commercial enquiries about our software services, please visit Ebisu

Protein Fold Recognition

These methods will identify putative folds and structural domains for a sequence without known structure.
GenTHREADER  Rapid fold recognition, matching your sequence against a library of whole PDB chains.
pGenTHREADER  Highly sensitive fold recognition using profile-profile comparison (whole chain library).
pDomTHREADER  Highly sensitive homologous domain recognition using profile-profile comparison (domain library).

Protein Structure Feature Recognition

These methods annotate sequences with the location of important structural features.
PSIPRED  Accurate protein secondary structure prediction.
METSITE  A method for identifying metal binding sites in protein 3D structures
DeepMetaPSICOV  Predicts structural contacts between protein residues

Transmembrane Topology Prediction

These methods identify the topology of putative transmembrane proteins.
MEMSAT3  Transmembrane protein topology predcition.
MEMSATSVM  Improved transmembrane protein topology prediction using SVMs. This method is capable of differentiating signal peptides from transmembrane helices.
MEMEMBED  Prediction of Membrane protein orientation.

3D Protein Modelling

Our latest experimental method will generate a homology model for a given sequence.
BioSerf  Automated homology and de-novo modelling server, utilising Modeller, PSIBLAST, pGenTHREADER and HHBlits.
DomSerf  Automated homology modelling of protein domains.
DMPfold  Deep learning-based Protein structure modelling

Annotation of Protein Sequence Features

These methods identify protein sequence features which are important for protein structure and function.
DomPred  Identifies putative domain boundaries in sequences.
DISOPRED  Identifies residues which are likely to be natively unfolded (disordered).

Protein Interface Characterisation

Characterisation of protein-protein interfaces.
HSPred  Interface Hot Spot Prediction

Function Prediction

Feature-based protein function prediction from amino acid sequence.
FFPred  Integrated function prediction

Web Services

We now offer all our online methods via REST. Please consult our REST guide for further details
REST REST service guide

Legacy Services

The following services are retired. Data and access is provided on an "as is" basis.
GTD Genomic Threading Database
COPS Comparison Of Protein Structure classifications